Dual MMP7-Proximity-Activated and Folate Receptor-Targeted Nanoparticles for siRNA Delivery

Dual MMP7-Proximity-Activated and Folate Receptor-Targeted Nanoparticles for siRNA Delivery

A dual-targeted siRNA nanocarrier has been synthesized and validated that is selectively activated in environments where there is colocalization of two breast cancer hallmarks, elevated matrix metalloproteinase (MMP) activity and folate receptor overexpression. This siRNA nanocarrier is self-assembled from two polymers containing the same pH-responsive, endosomolytic core-forming block but vary...

MMP-Responsive, Proximity-activated Targeting Polymeric Nanoparticles for siRNA Delivery

SUMMARY A smart polymeric nanoparticle (SPN) with matrix metalloproteinase-7 (MMP-7) dependent proximityactivated targeting (PAT) has been designed and tested for targeted intracellular siRNA delivery to MMP-7 overexpressing tissues (i.e., tumor metastases). With this novel PAT-SPN design, a removable PEG corona mitigates cytotoxicity and nonspecific uptake in normal tissues. Exposure to MMP (i...

Folate-modified lipid–polymer hybrid nanoparticles for targeted paclitaxel delivery

The purpose of this study was to develop a novel lipid-polymer hybrid drug carrier comprised of folate (FA) modified lipid-shell and polymer-core nanoparticles (FLPNPs) for sustained, controlled, and targeted delivery of paclitaxel (PTX). The core-shell NPs consist of 1) a poly(ε-caprolactone) hydrophobic core based on self-assembly of poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolact...

Folate receptor-targeted anti-cancer agent delivery

Transferrin Receptor Targeted Delivery Of Sirna For Gene Therapy

TRANSFERRIN RECEPTOR TARGETED DELIVERY OF SIRNAFOR GENE THERAPY